Comparison 7. Unplanned subgroup analyses ‐ Immunotherapy versus control.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Systemic reaction to field or challenge sting by history of prior systemic reaction	6	205	Risk Ratio (M‐H, Random, 95% CI)	0.10 [0.03, 0.28]
1.1 No prior systemic reaction to insect sting	2	55	Risk Ratio (M‐H, Random, 95% CI)	0.29 [0.01, 6.50]
1.2 Prior systemic reaction to insect sting	4	150	Risk Ratio (M‐H, Random, 95% CI)	0.08 [0.03, 0.26]
2 Systemic adverse reaction to treatment by history of prior systemic reaction	6		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
2.1 No prior systemic reaction to insect sting	2	59	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
2.2 Prior systemic reaction to insect sting	4	226	Risk Ratio (M‐H, Random, 95% CI)	8.16 [1.53, 43.46]