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. 2021 Dec 23;12:769793. doi: 10.3389/fphar.2021.769793

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Copyright © 2021 Qiao, Fang, Zhu, Xiang, Xu, Sun, Chen and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Total flavone of Abelmoschus manihot L. Medic (TFA) attenuates colitis in the 2,4,6-trinitrobenzene sulfonic acid (TNBS)‐induced colitis in mice. (A) Bodyweight change. (B) Disease activity index. (C) After sacrificing, colon damage was evaluated by colon length. (D) Length and weight of colon (from the appendix to the anus). (E) Colon gross morphological damage index (CMDI) score of each group. (F) Histological appearance of mice colonic mucosa (H and E, magnification ×100). Data are shown as the mean ± SEM. ***p < 0.001 compared with sham-1 and sham-2 groups, ^# p < 0.05, ^## p < 0.01, ^### p < 0.001 compared with the model group.