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. 2021 Dec 23;9:785302. doi: 10.3389/fbioe.2021.785302

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Copyright © 2021 Lan, Zhu, Chen, Zhang, Zou and Zeng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Biocompatibility and antibacterial effect evaluation of the S₄Q₄G₄ hydrogel. (A,B) Fluorescent staining (A) and CCK-8 assay (B) of 3T3 cells seeded on the S₄Q₄G₄ hydrogel for 1 and 2 days. (C) Fluorescent immunohistochemical staining with CD68 (green) and DAPI (blue) for macrophages after 4 and 14 days of subcutaneous implantation. (D) Hemolysis ratio of the S₄Q₄G₄ hydrogel, deionized water, and saline solution. (E) Antibacterial activity against Staphylococcus aureus and Escherichia coli of S₄Q₄G₄ hydrogels. CCK-8, Cell Counting Kit-8.