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. 2021 Feb 1;28(1):325–342. doi: 10.1080/10717544.2021.1879313

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© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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graphic file with name IDRD_A_1879313_F0014a_C.jpg — Molecular docking models of matrine binding to the six core targets. (A) Matrine was docked to the surface of AKT1. (B) The binding interaction between matrine and AKT1 protein. (C) Matrine was docked to the surface of TP53. (D) The binding interaction between matrine and TP53 protein. (E) Matrine was docked to the surface of TNF. (F) The binding interaction between matrine and TNF protein. (G) Matrine was docked to the surface of IL6. (H) The binding interaction between matrine and IL6 protein. (I) Matrine was docked to the surface of BCL2L1. (J) The binding interaction between matrine and BCL2L1 protein. (K) Matrine was docked to the surface of ATM. (L) The binding interaction between matrine and ATM protein.

graphic file with name IDRD_A_1879313_F0014b_C.jpg — Molecular docking models of matrine binding to the six core targets. (A) Matrine was docked to the surface of AKT1. (B) The binding interaction between matrine and AKT1 protein. (C) Matrine was docked to the surface of TP53. (D) The binding interaction between matrine and TP53 protein. (E) Matrine was docked to the surface of TNF. (F) The binding interaction between matrine and TNF protein. (G) Matrine was docked to the surface of IL6. (H) The binding interaction between matrine and IL6 protein. (I) Matrine was docked to the surface of BCL2L1. (J) The binding interaction between matrine and BCL2L1 protein. (K) Matrine was docked to the surface of ATM. (L) The binding interaction between matrine and ATM protein.