Skip to main content
. 2021 Dec 15;10:e66955. doi: 10.7554/eLife.66955
Parameter Description Value
Unstable switch (4B) Unstable CHE-1 switch, average lifetime of ~10 days
C Number of CHE-1 protein molecules 900
M Number of che-1 mRNA molecules 7
O Number of che-1 promoters 1
OT Number of target genes 500
fO Binding rate of CHE-1 on che-1 or target gene promoters 0.03 s–1
bO Unbinding rate of CHE-1 from che-1 promoter 100 s–1
bT Unbinding rate of CHE-1 from target gene promoters 100 s–1
fM che-1 mRNA production rate 0.0302 s–1
bM che-1 mRNA degradation rate 0.00083 s–1
fC CHE-1 protein production rate 0.0274 s–1
bC CHE-1 protein degradation rate 0.00024 s–1
Stable switch (4B) Highly stable switch, slower unbinding rate of CHE-1 from its own promoter
bO Unbinding rate of CHE-1 from che-1 promoter 0.1 s–1
fM che-1 mRNA production rate 0.0059 s–1
fC CHE-1 protein production rate 0.0261 s–1
bC CHE-1 protein degradation rate 0.00023 s–1
Stable switch (4E) Highly stable switch, depleted to 100 CHE-1
bO Unbinding rate of CHE-1 from che-1 promoter 0.1 s–1
fM che-1 mRNA production rate 0.0059 s–1
bC CHE-1 protein degradation rate 0.0019 s–1
fC CHE-1 protein production rate 0.024 s–1
bP Target mRNA degradation rate 0.0008 s–1
fP Target mRNA production rate 0.09 s–1
Unstable switch (4E) Unstable switch, depleted to 100 CHE-1
bO Unbinding rate of CHE-1 from che-1 promoter 10 s–1
bT Unbinding rate of CHE-1 from target gene promoters 10 s–1
bC CHE-1 protein degradation rate 0.00076 s–1
fC CHE-1 protein production rate 0.026 s–1
bP Target mRNA degradation rate 0.0004 s–1
fP Target mRNA production rate 0.016 s–1