Table 1.

Pharmacokinetics of semaglutide [33–36]

Characteristics	Semaglutide (s.c. injection)	Semaglutide (oral)
Absorption
Absolute bioavailability	89%	0.4–1%
Steady state plasma conc	65 ng/ml (0.5 mg weekly once)	6.7 nmol/L (7 mg once daily)
	123 ng/ml (1 mg weekly once)	14.6 nmol/L (14 mg once daily)
Time to achieve steady state conc	4–5 weeks	4–5 weeks
Time to achieve maximum conc	1–3 days	01 h
Distribution
Volume of distribution	12.5 Litres	8 Litres
Protein binding	> 99%	> 99%
Metabolic pathway	Proteolytic degradation followed by fatty acid oxidation	Proteolytic degradation followed by fatty acid oxidation
Elimination profile
Elimination t1/2	01 week	01 week
Rate of clearance	0.05 Litres/Hr	0.04 L/Hr