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. 2021 Dec 30;2021:1328444. doi: 10.1155/2021/1328444

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Copyright © 2021 Qibo Wang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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PKM2 knockdown weakens cell proliferation and metabolic reprogramming mediated by ZC3H13 in HCC cells. (a) RT-qPCR detecting the mRNA expression of PKM2 for Hep3B as well as HUH-7 cells transfected by siRNAs against PKM2. (b, c) CCK-8 examining the effects of PKM2 knockdown on cell growth for Hep3B as well as HUH-7 cells with ZC3H13 loss. (d, e) The effects of silencing or overexpressing PKM2 on clone formation of Hep3B as well as HUH-7 cells with ZC3H13 knockdown. (f, g) The effects of PKM2 knockdown on glucose uptake and lactate production in Hep3B and HUH-7 cells with ZC3H13 deficiency.^∗P < 0.05; ^∗∗∗∗p < 0.0001.