TABLE 2.
Immunohistochemistry results for third eyelid lymphoid tissue from clinically normal sheep in flocks with scrapie
| Scrapie agent status | Outcome | No. of sheep | No. of sheep with the following IHC results with eyelid tissuea
|
|
|---|---|---|---|---|
| Positive | Negative | |||
| Uninfectedb | Euthanatized while healthy | 120 | 0 | 120 |
| Infectedc | Euthanatized while healthy | 13 | 9 | 4 |
| Progressed to clinical diseased | 28 | 27 | 1 | |
a
Results of immunohistochemistry assay performed with MAb F89/160.1.5.
b
Sheep without scrapie showed no PrP-Sc in brain, tonsil, retropharyngeal lymph node, or submandibular lymph node.
c
Sheep with scrapie were positive by PrP-Sc immunostaining of the medulla oblongata at the level of the obex.
d
Sheep were clinically normal when sampled and progressed to clinical disease and were confirmed to have scrapie 3 to 20 months after a positive result with an eyelid biopsy specimen.