Table 3.

Subgroup analysis for the association between depression and anxiety the participants among two groups by Disease Onset.

Item	EOP					LOP
	Case (n = 228)	Control (n = 996)	OR (95%CI)	AOR (95%CI)a	P	Case (n = 98)	Control (n = 563)	OR (95%CI)	AOR (95%CI)a	P
	N (%)	N (%)				N (%)	N (%)
Anxiety (GAD-7b ≥8)	68 (29.8)	284 (29.3)	1.03 (0.75–1.41)	1.06 (0.74–1.52)	0.742	26 (26.5)	88 (16.4)	1.84 (1.11–3.04)	1.47 (1.05–2.34)	0.033
Depression (PHQ-9c ≥8)	83 (36.4)	337 (34.8)	1.07 (0.80–1.45)	1.08 (0.77–1.50)	0.656	35 (35.7)	114 (21.3)	2.06 (1.30–3.27)	1.85 (1.15–3.02)	0.012

^a Adjusted for age, sex, annual income, educational level, smoking, alcohol, and drinking;

^b GAD-7, Generalized Anxiety Disorder-7;

^c PHQ-9, Patient Health Questionnaire-9;

P value for adjusted OR, estimated from the multivariable logistic regression model.

OR, unadjusted odds ratio; AOR, adjusted odds ratio; CI, confidence interval.