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. 2021 Dec 24;12:800978. doi: 10.3389/fimmu.2021.800978

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Copyright © 2021 Holt, Michelsen, Shahini, Bjørkelund, Bendz, Massey, Schjalm, Halvorsen, Broch, Ueland, Gullestad, Nilsson, Aukrust, Mollnes and Louwe

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Plasma levels of alternative complement pathway components Factor B and C3bBbP are increased in patients with heart failure and do not correlate. Plasma levels of (A) complement factor B (FB), (B) C3bBbP, and (C) TCC were measured in 343 heart failure patients and 27 controls. Correlation between plasma levels of (D) Factor B and C3bBbP, and (E) C3bBbP and TCC levels. NYHA, New York Heart Association functional class; TCC, terminal complement complex; Values are mean ± SEM *p < 0.05, **p < 0.01, ****p < 0.0001.