Fig. 1.

Decrease of CD56^dim CD16⁺ NK cell subset frequency in EBV+ HL patients compared to EBV- HL patients. Thawed PBMCs from EBV+ and EBV- HL patients and healthy controls (HC) were analyzed by flow cytometry. Frequencies of CD56^dim CD16⁺ a, CD56^dim CD16^bright b and CD56^- CD16⁺ c NK cells of EBV+ HL (n=10; filled circles), EBV- HL (n=26; open circles) and HC (n=5, triangles). d Frequencies of NKG2A⁺ KIR^- (N⁺/K^-), NKG2A^- KIR⁺ (N^-/K⁺), CD62L⁺ and CD57⁺ cells within CD56^dim NK cells of EBV+ HL (dark gray, n=10), EBV- HL (light gray, n=26) and HC (white, n=5). Horizontal lines in panels a to c indicate the mean value. Floating bars in panel d indicate mean and minimum and maximum values. Significance was determined by the one-way ANOVA test with Tukey’s multiple comparisons test