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. 2021 Dec 18;79(1):57. doi: 10.1007/s00018-021-04065-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — (A, B) Synergistic effect of EGFR and AT1R on protein expression of known SRF target genes in stable transfected HEK293-AT1R clones B6 and D5. The tables show the data from three independent experiments. Synergistic effect of EGFR and AT1R on (A) AP1- and (B) EGR-mediated transcriptional activity in HEK293 cells transfected with AT1R. T = 24 h. 1 nmol/l AII, 10 µg/l EGF, N(AP1) = 12, N(EGR) = 24. *p < 0.05. (D) Graphical summary of AT1R-EGFR-synergism

Fig. 6 — (A, B) Synergistic effect of EGFR and AT1R on protein expression of known SRF target genes in stable transfected HEK293-AT1R clones B6 and D5. The tables show the data from three independent experiments. Synergistic effect of EGFR and AT1R on (A) AP1- and (B) EGR-mediated transcriptional activity in HEK293 cells transfected with AT1R. T = 24 h. 1 nmol/l AII, 10 µg/l EGF, N(AP1) = 12, N(EGR) = 24. *p < 0.05. (D) Graphical summary of AT1R-EGFR-synergism