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. 2021 May 24;71(1):111–120. doi: 10.1007/s00262-021-02966-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Survival analysis of patients stratified based on PTCH1 status or TMB in the MSKCC cohort a and b OS in patients with and without the PTCH1 mutation in the MSKCC pan-cancer (a) and MSKCC CRC cohort (b). c-f OS curves were plotted for the patients stratified based on the TMB level in the MSKCC cohort. The cutoffs used in this cohort were the top 10% (c), 20% (d), 45% (e), and 50% (f).