Table 2.

Multivariate Cox proportional hazard analyses of progression-free survival

	Single-lipid analysis		Multiple-lipid analysis
Variables	Hazard ratio	P	Hazard ratio	P
LDL-cholesterola	0.87 (0.82–0.93)	< 0.001	0.86 (0.78–0.94)	0.001
HDL-cholesterola	0.81 (0.68–0.95)	0.014	0.83 (0.70–0.98)	0.027
Total cholesterola	0.94 (0.90–0.98)	0.007
Lauric acidb	0.80 (0.61–0.96)	0.015	0.80 (0.58–0.99)	0.040
Myristic acidb	0.89 (0.81–0.98)	0.022
Myristoleic acidc	0.86 (0.76–0.99)	0.035	0.96 (0.80–1.13)	0.653
Palmitic acidd	0.93 (0.85–1.01)	0.100
Palmitoleic acidb	0.96 (0.91–1.02)	0.209
Stearic acidd	0.70 (0.51–0.96)	0.028	1.83 (0.95–3.46)	0.069
Oleic acidd	0.94 (0.87–1.02)	0.150
Linoleic acidd	0.88 (0.81–0.96)	0.005
γ-linolenic acidc	0.98 (0.95–1.01)	0.141
Linolenic acidc	0.99 (0.97–1.00)	0.061
Arachidic acidc	0.91 (0.84–0.99)	0.027
Eicosenoic acidc	0.94 (0.87–1.02)	0.152	0.94 (0.84–1.06)	0.324
Eicosadienoic acidc	0.90 (0.83–0.98)	0.017
Eicosatrienoic acidc	0.95 (0.87–1.04)	0.245
Dihomo-γ-linolenic acidc	0.98 (0.97–0.99)	0.036	1.00 (0.98–1.02)	0.818
Arachidonic acidb	0.97 (0.94–1.01)	0.150
Eicosapentaenoic acidb	0.99 (0.93–1.06)	0.867
Behenic acidc	0.96 (0.92–0.99)	0.032
Docosatetraenoic acidc	0.93 (0.84–1.02)	0.129
Docosapentaenoic acidc	0.98 (0.95–1.01)	0.121
Lignoceric acidc	0.96 (0.93–1.00)	0.072
Docosahexaenoic acidb	0.96 (0.91–1.00)	0.080
Nervonic acidb	0.89 (0.74–1.07)	0.227

The hazard ratio was adjusted for sex, smoking status, Eastern Cooperative Oncology Group performance status, programmed death ligand-1 expression, and treatment line (2nd vs. ≥ 3rd). Total cholesterol, myristoleic acid, and linoleic acid were excluded from the multiple-lipid analysis because of their strong correlations with other lipids, and the results of the other combinations of the excluded lipids are presented in Supplementary Table 5

^aper 10 mg/dL increase

^bper 10 mg/dL increase

^cper 1 mg/dL increase

^dper 100 mg/dL increase