Table 3.

Multivariate cox proportional hazard analyses of overall survival

	Single-lipid analysis		Multiple-lipid analysis
Variables	Hazard ratio	P	Hazard ratio	P
LDL-cholesterola	0.87 (0.80–0.94)	< 0.001	0.86 (0.77–0.96)	0.005
HDL-cholesterola	0.76 (0.62–0.93)	0.009	0.81 (0.66–0.99)	0.035
Total cholesterola	0.95 (0.90–0.99)	0.036
Lauric acidb	0.91 (0.68–1.07)	0.375
Myristic acidb	0.93 (0.82–1.04)	0.251
Myristoleic acidc	0.92 (0.79–1.05)	0.289	0.91 (0.75–1.11)	0.346
Palmitic acidd	0.98 (0.89–1.08)	0.678
Palmitoleic acidb	1.00 (0.94–1.05)	0.916
Stearic acidd	0.85 (0.58–1.23)	0.405	1.65 (0.90–3.01)	0.112
Oleic acidd	1.00 (0.92–1.09)	0.915
Linoleic acidd	0.87 (0.79–0.97)	0.014
γ-linolenic acidc	1.00 (0.96–1.03)	0.829
Linolenic acidc	0.99 (0.98–1.01)	0.554
Arachidic acidc	0.97 (0.88–1.06)	0.516
Eicosenoic acidc	0.99 (0.89–1.08)	0.783
Eicosadienoic acidc	0.92 (0.83–1.01)	0.105
Eicosatrienoic acidc	0.98 (0.88–1.09)	0.759
Dihomo-γ-linolenic acidc	0.99 (0.98–1.01)	0.441	1.00 (0.98–1.02)	0.831
Arachidonic acidb	0.97 (0.93–1.02)	0.296
Eicosapentaenoic acidb	1.02 (0.95–1.08)	0.513
Behenic acidc	0.96 (0.91–1.00)	0.086
Docosatetraenoic acidc	0.96 (0.85–1.07)	0.479
Docosapentaenoic acidc	1.00 (0.97–1.03)	0.810
Lignoceric acidc	0.95 (0.90–0.99)	0.028	0.99 (0.93–1.06)	0.808
Docosahexaenoic acidb	0.98 (0.92–1.03)	0.400
Nervonic acidb	1.06 (0.85–1.33)	0.581

The hazard ratio was adjusted for sex, body mass index, Eastern Cooperative Oncology Group performance status, pathology, and programmed death ligand-1 expression. Total cholesterol, myristic acid, linoleic acid, and lignoceric acid were excluded from the multiple-lipid analysis because of their strong correlations with other lipids, and the results of the combination of the excluded lipids are presented in Supplementary Table 7

^aper 10 mg/dL increase

^bper 10 mg/dL increase

^cper 1 mg/dL increase

^dper 100 mg/dL increase