Table 4.

Treatment of interstitial pneumonia in the case group

Case	Age (years)	Sex	Immune checkpoint inhibitors	History of interstitial pneumonia	Radiological pattern of interstitial pneumonia	CTCAE grade of pneumonitis	Initial therapy of corticosteroids	Other treatment	Results of treatment
1	58	M	Pembrolizumab	Cause unknown; from the time of lung cancer diagnosis (idiopathic interstitial pneumoniaa)	Usual interstitial pneumonia	Grade 3	Methylprednisolone sodium succinate drip infusion in vein 500 mg 3 days	Tacrolimus oral administration 4 mg	Oral corticosteroid administration continued while IV prednisolone was tapered Remission of interstitial pneumonia
2	74	M	Nivolumab	Nivolumab-induced interstitial pneumoniab	Organizing pneumonia pattern	Grade 3	Prednisolone sodium succinate drip infusion in vein 20 mg	None	Oral corticosteroid administration continued while IV prednisolone was tapered Remission of interstitial pneumonia
3	74	M	Atezolizumab	Cause unknown; from the time of lung cancer diagnosis (idiopathic interstitial pneumoniaa)	Organizing pneumonia pattern	Grade 2	Oral prednisolone 30 mg (0.5 mg/kg)	None	Oral corticosteroid administration continued while IV prednisolone was tapered Remission of interstitial pneumonia
4	64	M	Nivolumab	Radiation pneumonitis	Organizing pneumonia pattern	Grade 3	Methylprednisolone sodium succinate drip infusion in vein 1000 mg 3 days	None	Oral corticosteroid administration continued while IV prednisolone was tapered Remission of interstitial pneumonia
5	75	M	Pembrolizumab	Pembrolizumab-induced interstitial pneumoniab	Organizing pneumonia pattern	Grade 3	Prednisolone sodium succinate drip infusion in vein 50 mg (1 mg/kg)	None	Oral corticosteroid administration continued while IV prednisolone was tapered Remission of interstitial pneumonia
6	68	M	Nivolumab	Nivolumab-induced interstitial pneumoniab	Organizing pneumonia pattern	Grade 4c	Methylprednisolone sodium succinatedrip infusion in vein 1000 mg 3 days	None	Prednisolone sodium succinate IV infusion 60 mg (1 mg/kg) death due to disease progression
7	69	M	Pembrolizumab	Pembrolizumab-induced interstitial pneumoniab	Organizing pneumonia pattern	Grade 1	Oral prednisolone 20 mg	None	Oral corticosteroid administration continued while IV prednisolone was tapered Remission of interstitial pneumonia
8	81	M	Nivolumab	Radiation pneumonitis	Nonspecific interstitial pneumonia	Grade 3	Prednisolone sodium succinate drip infusion in vein 60 mg (1 mg/kg)	None	Oral corticosteroid administration continued while IV prednisolone was tapered Remission of interstitial pneumonia
9	50	M	Nivolumab	Radiation pneumonitis	Organizing pneumonia pattern	Grade 2	Prednisolone sodium succinate drip infusion in vein 70 mg (1 mg/kg)	None	Oral corticosteroid administration continued while IV prednisolone was tapered Remission of interstitial pneumonia
10	71	M	Nivolumab	Radiation pneumonitis	Nonspecific interstitial pneumonia	Grade 3	Prednisolone sodium succinate drip infusion in vein 20 mg	None	Continue oral administration while tapering prednisolone interstitial pneumonia was remitted
11	76	F	Nivolumab	Radiation pneumonitis	Organizing pneumonia pattern	Grade 1	None (without hope for corticosteroids)	None	Oral corticosteroid administration continued while IV prednisolone was tapered Remission of interstitial pneumonia

CTCAE common terminology criteria for adverse events; IV intravenous

^aIdiopathic interstitial pneumonia is an interstitial pneumonia of unknown cause

^bImmune checkpoint inhibitor-induced interstitial pneumonia improved initially and then reoccurred when patients were re-challenged with immune checkpoint inhibitors

^cRespiratory failure present