TABLE 1.
In vitro susceptibility of clinical mold isolates to itraconazole as determined by the reference microdilution broth methoda
| Species (no. of isolates) | MIC (μg/ml)c
|
||
|---|---|---|---|
| Range | 50% | 90% | |
| Fusarium spp.b (13) | >8.0 | >8.0 | >8.0 |
| P. boydii (5) | 0.5–1.0 | 1.0 | |
| Rhizopus spp. (6) | 1.0–>8.0 | 2.0 | |
| A. flavus (10) | 0.25–1.0 | 0.25 | 1.0 |
| A. fumigatus (12) | 0.5–1.0 | 1.0 | 1.0 |
| A. niger (1) | 0.5 | ||
| A. terreus (1) | 0.5 | ||
| P. variotii (1) | 4.0 | ||
| Acremonium sp. (1) | 1.0 | ||
a
Reference microdilution method MICs read at 48 h of incubation (NCCLS, M38-P).
b
Includes F. solani (five isolates), F. oxysporum (five isolates) and three isolates of Fusarium spp. (not further identified).
c
50% and 90%, MICs at which 50 and 90% of isolates are inhibited, respectively.