Table 2.
Clinical features and association analysis between the conventional SCC cohort and the non-SCC cohort
| Variables | Total | SCC | Non-SCC | P value | ||||
|---|---|---|---|---|---|---|---|---|
| N | % | N | % | N | % | |||
| Sex | Male | 299 | 86.2 | 286 | 87.7 | 13 | 61.9 | 0.004 |
| Female | 48 | 13.8 | 40 | 12.3 | 8 | 38.1 | ||
| Alcohol | No | 254 | 73.2 | 234 | 71.8 | 20 | 95.2 | 0.02 |
| Yes | 93 | 26.8 | 92 | 28.2 | 1 | 4.8 | ||
| Smoke | No | 52 | 15.0 | 43 | 13.2 | 9 | 42.9 | 0.001 |
| Yes/ex | 295 | 85.0 | 283 | 86.8 | 12 | 57.1 | ||
| Site | Supraglottis | 69 | 19.9 | 58 | 17.8 | 11 | 52.4 | < 0.001 |
| Glottis | 251 | 72.3 | 248 | 76.1 | 3 | 14.3 | ||
| Subglottis | 7 | 2 | 0 | 0 | 7 | 33.3 | ||
| Transglottis | 20 | 5.77 | 20 | 6.1 | 0 | 0 | ||
| Fixation | No | 296 | 85.3 | 281 | 86.2 | 15 | 71.43 | 0.1 |
| Yes | 51 | 14.7 | 45 | 13.8 | 6 | 28.6 | ||
| Stage | I | 166 | 47.8 | 158 | 48.5 | 8 | 38.1 | 0.66 |
| II | 58 | 16.7 | 53 | 16.3 | 5 | 23.8 | ||
| III | 69 | 19.9 | 65 | 20.0 | 4 | 19.1 | ||
| IV | 54 | 15.6 | 50 | 15.3 | 4 | 19.1 | ||
| Grade | G1 | 58 | 16.7 | 49 | 15.0 | 9 | 42.9 | < 0.001 |
| G2 | 237 | 68.3 | 232 | 71.2 | 5 | 23.8 | ||
| G3 | 20 | 11.5 | 35 | 10.7 | 5 | 23.8 | ||
| Missing | 12 | 3.5 | 10 | 3.1 | 2 | 9.5 | ||
| Treatment | TLM | 266 | 76.7 | 253 | 77.6 | 13 | 61.9 | < 0.001 |
| OPHL | 26 | 7.5 | 25 | 7.7 | 1 | 4.8 | ||
| CTRA | 2 | 0.6 | 0 | 0.0 | 2 | 9.5 | ||
| TL | 48 | 13.8 | 48 | 14.7 | 0 | 0.0 | ||
| Other | 5 | 1.4 | 0 | 0.0 | 5 | 23.8 | ||
P values estimated by Fisher’s exact test
Legend: SCC squamous cell carcinoma; TLM transoral laser microsurgery; OPHL open partial horizontal laryngectomy; CTRA crico-tracheal resection and anastomosis; TL total laryngectomy