Table 3.
Univariate OS and DSS analysis
| Variables | Overall survival (OS) | Disease-specific survival (DSS) | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
| Age | 1.06 | 1.02–1.09 | 0.001 | 1.02 | 0.97–1.08 | 0.363 |
| Sex (female vs male) | 1.13 | 0.47–2.70 | 0.78 | 2.04 | 0.66–6.32 | 0.219 |
| Smoke (yes vs no) | 2.2 | 0.68–7.16 | 0.19 | 2.89 | 0.38–21.93 | 0.304 |
| Alcohol (yes vs no) | 0.81 | 0.38–1.71 | 0.58 | 1.21 | 0.42–3.48 | 0.728 |
| Type (non-SCC vs SCC) | 0.56 | 0.13–2.41 | 0.44 | 0.54 | 0.07–4.42 | 0.568 |
| Supraglottic | Reference | – | – | Reference | – | – |
| Glottic | 0.8 | 0.38–1.67 | 0.551 | 0.99 | 0.31–3.19 | 0.99 |
| Subglottic | 0 | 0 | 1 | 0 | 0 | 1 |
| Transglottic | 1.61 | 0.50–5.16 | 0.427 | 1.12 | 0.12–10.25 | 0.92 |
| Fixation (yes vs no) | 3.14 | 1.59–6.23 | 0.001 | 4.38 | 1.58–12.16 | 0.005 |
| Stage I | Reference | – | – | Reference | – | – |
| Stage II | 2.68 | 0.97–7.40 | 0.057 | 1.12 | 0.1–12.33 | 0.929 |
| Stage III | 3.14 | 1.20–8.26 | 0.02 | 3.29 | 0.55–19.68 | 0.193 |
| Stage IV | 6.09 | 2.45–15.15 | < 0.001 | 14.49 | 3.16–66.53 | 0.001 |
| G1 | 0.43 | 0.13–1-43 | 0.17 | 0.00 | 0 - | 1 |
| G2 | Reference | – | – | Reference | – | – |
| G3 | 1.69 | 0.77–3.71 | 0.19 | 1.88 | 0.60–5.91 | 0.28 |
| TLM | 0.29 | 0.14–0.58 | 0.001 | 0.1 | 0.03–0.29 | < 0.001 |
| OPHL | 0.41 | 0.11–1.44 | 0.163 | 0.2 | 0.02–1.57 | 0.125 |
| CTRA/others | 0.33 | 0.04–2.75 | 0.31 | 0.3 | 0.03–3.18 | 0.32 |
| TL | Reference | – | – | Reference | – | – |
Legend: SCC squamous cell carcinoma; TLM transoral laser microsurgery; OPHL open partial horizontal laryngectomy; CTRA crico-tracheal resection and anastomosis; TL total laryngectomy