Table 4.
Univariate DFS and TLFS analysis
| Variables | Disease-free survival (DFS) | Total laryngectomy-free survival (TLFS) | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
| Age | 0.99 | 0.97–1.02 | 0.702 | 0.96 | 0.91–1 | 0.073 |
| Sex (female vs male) | 1.67 | 0.84–3.33 | 0.146 | 1.27 | 0.28–5.8 | 0.76 |
| Smoke (yes vs no) | 0.55 | 0.29–1.05 | 0.071 | 0.93 | 0.2–4.24 | 0.92 |
| Alcohol (yes vs no) | 0.79 | 0.41–1.50 | 0.463 | 0.6 | 0.13–2.75 | 0.51 |
| Type (non-SCC vs SCC) | 4.46 | 2.29–8.69 | < 0.001 | 4.4 | 1.19–16.26 | 0.026 |
| Supraglottic | Reference | – | – | Reference | – | – |
| Glottic | 0.31 | 0.18–0.56 | < 0.001 | 0.47 | 0.12–1.87 | 0.28 |
| Subglottic | 3.13 | 1.16–8.45 | 0.024 | 6.61 | 1.1–39.78 | 0.039 |
| Transglottic | 0.15 | 0.02–1.10 | 0.061 | 1.71 | 0.18–16.45 | 0.64 |
| Fixation (yes vs no) | 2.19 | 1.15–4.19 | 0.018 | 4.07 | 0.88–18.76 | 0.07 |
| Stage I | Reference | – | – | Reference | – | – |
| Stage II | 4.04 | 1.73–9.46 | 0.001 | 8.1 | 0.84–77.87 | 0.07 |
| Stage III | 3.49 | 1.49–8.18 | 0.004 | 11.72 | 1.31–104.94 | 0.028 |
| Stage IV | 7.28 | 3.26–16.27 | < 0.001 | 39.76 | 4.44–355.89 | 0.001 |
| G1 | 1.02 | 0.49–2.12 | 0.95 | 0.91 | 0.19–4.30 | 0.91 |
| G2 | Reference | – | – | 1 | 1 | |
| G3 | 1.19 | 0.53–2.67 | 0.67 | 2.08 | 0.44–9.81 | 0.35 |
| TLM | 0.43 | 0.22–0.84 | 0.013 | Reference | – | – |
| OPHL | 0.72 | 0.25–2.05 | 0.543 | 5.49 | 1.65–18.25 | 0.006 |
| CTRA/Others | 1.37 | 0.38–5.01 | 0.63 | < 0.01 | < 0.01– | 1 |
| TL | Reference | – | – | |||
Legend: SCC squamous cell carcinoma; TLM transoral laser microsurgery; OPHL open partial horizontal laryngectomy; CTRA crico-tracheal resection and anastomosis; TL total laryngectomy