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. 2022 Jan 7;10:3. doi: 10.1038/s41413-021-00171-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — E2-induced BMP and HOXC6 expression in DMSCs. a qRT-PCR of BMP2 and HOXC6 at 4 h upon E2 treatment in DMSCs. b Depletion of HOXC6 in DMSCs via siRNA by qRT-PCR. c Alkaline phosphatase staining and quantification of HOXC6-depleted DMSCs after 5 days of treatment in osteogenic media with and without E2. d Alizarin Red S staining and quantification of HOXC6-depleted DMSCs after 14 days of treatment in osteogenic media with and without E2. Data are presented as the mean ± SEM (n = 3). For a, data are shown as fold expression of target genes after normalization to the control. For b, data are shown as fold expression of target genes after normalization to DMSC/siCtrl. For a and b, two groups were compared by two-tailed t-tests. For c and d, all groups were compared by two-way ANOVA with a Bonferroni post hoc test. Asterisks were assigned to P values with statistical significance (*P < 0.05; **P < 0.01; ***P < 0.001)