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. 2022 Jan 7;10:3. doi: 10.1038/s41413-021-00171-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — KDM6B is required for E2-mediated DMSC bone formation in vivo. Micro-CT images (a) and bone volume quantification (BV/TV) (b) of calvarial bone defects with scaffolds containing DMSC/shKDM6B and DMSC/Scrsh with and without E2. Scale bars, 1 mm. H&E staining images (c) and histomorphometric analysis for new bone area within calvarial bone defects (d) from mice with transplanted scaffolds seeded with DMSC/shKDM6B and DMSC/Scrsh with and without E2. Scale bars, 200 μm. e Immunostaining of KDM6B in bone tissue formed on scaffolds. Scale bars, 25 μm. Data are presented as the mean ± SEM (n = 4). For b and d, all the groups were compared by two-way ANOVA with a Bonferroni post hoc test. Asterisks were assigned to P values with statistical significance (*P < 0.05; **P < 0.01)