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. 2021 Jul 14;29(1):14–27. doi: 10.1038/s41418-021-00828-6

Fig. 1. CDK15 is upregulated in human colorectal cancer and is associated with patient survival probability.

Fig. 1

A Expression of CDK15 in human colon epithelial cell line CCD18-Co and colorectal cancer (CRC) cell lines. B Expression of CDK15 in 14 paired human clinical samples with CRC and adjacent tissues. Right panel: CDK15 protein expression levels normalized according to β-actin levels. C DNA level of CDK15 in normal and CRC tissues retrieved from the Oncomine database. D, E Representative immunohistochemical staining images of human CRC tissues elucidated by CDK15 antibody (40× and 100×; Scale bar: 50 μm). Statistical analysis performed for immunohistochemical staining, and CDK15 expression denoted as a positive percentage (Tissue specimens in D from the Affiliated Cancer Hospital of Zhengzhou University include 15 adjacent tissues and 20 tumor tissues; Commercial tissue microarray in E from Shanghai Outdo Biotech Company contains 84 paired tumor tissues with clinical information). F Relationship between CDK15 expression level and overall survival for tissue microarray. G Expression of CDK15 in patients with different clinical stages for tissue microarray. H Number of lymph node metastases (LNM) stratified by CDK15 expression level. Data statistical analysis performed using Student’s paired t-test in B, E; Student’s unpaired t-test in C, D, E, G, H; Kaplan–Meier analysis in F. Error bars represent mean ± SD.