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. 2021 Jul 7;27(19):5430–5439. doi: 10.1158/1078-0432.CCR-21-0005

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©2021 The Authors; Published by the American Association for Cancer Research

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs International 4.0 License.

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Figure 2. Impact of MYC gene expression on OS and PFS. A, A comparison of OS (years) in patients with low MYC expression (≤16.5 TPM; blue line), medium MYC expression (16.5–75 TPM; green line), and high MYC expression (≥75.0 TPM; red line) detected by RNAseq from the CoMMpass cohort. OS time (mean) was 5.3 years [95% confidence interval (CI): 5.0–5.7], 4.8 years (95% CI: 4.6–5.1), and 4.6 years (95% CI: 4.2–5.0) in low (n = 158), medium (n = 314), and high (n = 159) MYC expression cohorts, respectively. B, A comparison of PFS (years) in patients with low MYC expression (≤16.5 TPM; blue line), medium MYC expression (16.5–75 TPM; green line), and high MYC expression (≥75.0 TPM; red line) detected by RNAseq from the CoMMpass cohort. PFS time (median) was 3.1 years (95% CI: 2.4–3.9), 2.9 years (95% CI: 2.4–3.3), and 2.5 years (95% CI: 1.7–3.0) in low (n = 158), medium (n = 311), and high (n = 159) MYC expression cohorts, respectively. C, Pie charts showing the distribution of the MYC SV in association with MYC gene expression. — Impact of MYC gene expression on OS and PFS. A, A comparison of OS (years) in patients with low MYC expression (≤16.5 TPM; blue line), medium MYC expression (16.5–75 TPM; green line), and high MYC expression (≥75.0 TPM; red line) detected by RNAseq from the CoMMpass cohort. OS time (mean) was 5.3 years [95% confidence interval (CI): 5.0–5.7], 4.8 years (95% CI: 4.6–5.1), and 4.6 years (95% CI: 4.2–5.0) in low (n = 158), medium (n = 314), and high (n = 159) MYC expression cohorts, respectively. B, A comparison of PFS (years) in patients with low MYC expression (≤16.5 TPM; blue line), medium MYC expression (16.5–75 TPM; green line), and high MYC expression (≥75.0 TPM; red line) detected by RNAseq from the CoMMpass cohort. PFS time (median) was 3.1 years (95% CI: 2.4–3.9), 2.9 years (95% CI: 2.4–3.3), and 2.5 years (95% CI: 1.7–3.0) in low (n = 158), medium (n = 311), and high (n = 159) MYC expression cohorts, respectively. C, Pie charts showing the distribution of the MYC SV in association with MYC gene expression.