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. 2021 Jul 7;27(19):5430–5439. doi: 10.1158/1078-0432.CCR-21-0005

Figure 4.

Figure 4. Impact of different MYC SVs detected by NGS on OS and PFS. A, A comparison of OS (years) in patients with no MYC abnormality (no MYC SV, MAX SNV, monosomy 8, and trisomy 8; green line), patients with non-Ig insertion (blue line), patients with IgL rearrangements (all IgL insertions; red line), and all others (orange line) detected by WGS from the CoMMpass cohort. OS time (mean) was 5.5 (95% CI: 5.2–5.9) years (n = 320), 6.9 (95% CI: 6.3–7.4) years (n = 55), 4.3 (95% CI: 3.2–5.3) years (n = 28), and 5.4 (95% CI: 4.9–5.9) years (n = 142) in the no MYC abnormality, non-Ig insertion, IgL, and other group, respectively. B, A comparison of PFS (years) in patients with no MYC abnormality (no MYC SV, MAX SNV, monosomy 8, and trisomy 8; green line), patients with non-Ig insertion (blue line), patients with IgL rearrangements (all Ig insertions; red line), and all others (orange line) detected by WGS from the CoMMpass cohort. PFS time (median) was 3.2 (95% CI: 2.4–3.9) years (n = 318), 4.8 (95% CI: 3.6–6.1) years (n = 55), 1.4 (95% CI: 1.2–1.6) years (n = 28), and 3.1 (95% CI: 2.6–3.5) years (n = 141) in the no MYC abnormality, non-Ig insertion, IgL, and other group, respectively.

Impact of different MYC SVs detected by NGS on OS and PFS. A, A comparison of OS (years) in patients with no MYC abnormality (no MYC SV, MAX SNV, monosomy 8, and trisomy 8; green line), patients with non-Ig insertion (blue line), patients with IgL rearrangements (all IgL insertions; red line), and all others (orange line) detected by WGS from the CoMMpass cohort. OS time (mean) was 5.5 (95% CI: 5.2–5.9) years (n = 320), 6.9 (95% CI: 6.3–7.4) years (n = 55), 4.3 (95% CI: 3.2–5.3) years (n = 28), and 5.4 (95% CI: 4.9–5.9) years (n = 142) in the no MYC abnormality, non-Ig insertion, IgL, and other group, respectively. B, A comparison of PFS (years) in patients with no MYC abnormality (no MYC SV, MAX SNV, monosomy 8, and trisomy 8; green line), patients with non-Ig insertion (blue line), patients with IgL rearrangements (all Ig insertions; red line), and all others (orange line) detected by WGS from the CoMMpass cohort. PFS time (median) was 3.2 (95% CI: 2.4–3.9) years (n = 318), 4.8 (95% CI: 3.6–6.1) years (n = 55), 1.4 (95% CI: 1.2–1.6) years (n = 28), and 3.1 (95% CI: 2.6–3.5) years (n = 141) in the no MYC abnormality, non-Ig insertion, IgL, and other group, respectively.