Table 5. Predicted pathways of MTHFD1L-enriched genes.

Pathway	Description	Enriched genes	Gene count	P-value
hsa00240	Pyrimidine metabolism	NT5C3A, NME6, NME7, NME2, NME3, NME4, NME5, TYMP, NME1	9	<0.05
hsa00230	Purine metabolism	NT5C3A, NME6, NME7, NME2, NME3, NME4, NME5, NME1	8	<0.05
hsa01100	Metabolic pathways	NME2, NME3, NME4, NME5, TYMP, NME1, NT5C3A, MTHFD1L, NME6, NME7, MTHFD2, SARDH, PCK1	13	<0.05
hsa01130	Biosynthesis of antibiotics	NME6, NME7, NME2, NME3, NME4, NME5, PCK1, NME1	8	<0.05
hsa00670	One carbon pool by folate	MTHFD1L, MTHFD2	2	<0.05