Table 2.
Univariable and multivariable Cox proportional hazard and competing risk models predicting the development of advanced CKD (eGFR <30 ml/min/1.73 m2) following radical cystectomy.
| Cox proportional hazard |
Competing risk model | ||
|---|---|---|---|
| Univariable, HR (95% CI) | Multivariable, HR (95% CI) | Multivariable, HR (95% CI) | |
| Age at surgery (unit = 5 yr) | 1.15 (1.10, 1.20) | 1.08 (1.03, 1.12) | 1.01 (0.97, 1.05) |
| Sex (male vs female) | 1.82 (0.82, 4.07) | 0.84 (0.35, 2.04) | 0.93 (0.38, 2.28) |
| Preop hydronephrosis (yes vs no) | 1.50 (1.29, 1.76) | 0.76 (0.64, 0.91) | 0.69 (0.57, 0.83) |
| Baseline kidney function (1/Cr; unit = 0.1) | 0.75 (0.73, 0.78) | 0.75 (0.73, 0.78) | 0.79 (0.77, 0.82) |
| Comorbidity Index | 1.13 (1.11, 1.16) | 1.08 (1.06, 1.11) | 1.04 (1.01, 1.07) |
| Neoadjuvant chemo (yes vs no) | 0.98 (0.84, 1.16) | 1.05 (0.89, 1.24) | 1.03 (0.87, 1.21) |
| Adjuvant chemo (yes vs no) | 1.19 (1.00, 1.41) | 1.14 (0.95, 1.37) | 1.03 (0.86, 1.24) |
| Diversion type | |||
| Neobladder | Ref | Ref | Ref |
| Ileal conduit | 1.20 (0.98, 1.47) | 0.98 (0.79, 1.20) | 0.92 (0.75, 1.14) |
CI = confidence interval, Cr = creatinine (mg/dl); HR = hazard ratio; Ref = reference.