Table 3.
Multivariate logistic regression analysis to identify characteristics associated with the odds of developing an eGFR of <45 or <60 ml/min/1.73 m2 in the 12 mo following radical cystectomy in patients who did not receive neoadjuvant chemotherapy.
| eGFR <45 OR (95% CI) |
eGFR <60 OR (95% CI) |
|
|---|---|---|
| Age at surgery (unit = 5) | 1.05 (0.98, 1.12) | 1.13 (1.05, 1.22) |
| Sex (male vs female) | 0.43 (0.15, 1.22) | 0.25 (0.08, 0.82) |
| Preop hydronephrosis (yes vs no) | 0.24 (0.15, 0.39) | 0.16 (0.09, 0.29) |
| Postop hydronephrosis (yes vs no) | 3.55 (2.51, 5.01) | 5.51 (3.32, 9.14) |
| Baseline kidney function (1/Cr; unit = 0.1) | 0.78 (0.73, 0.83) | 0.69 (0.64, 0.73) |
| Charlson Comorbidity Index | 1.01 (0.97, 1.06) | 0.94 (0.90, 0.98) |
| Diversion type | ||
| Neobladder | Ref | Ref |
| Ileal conduit | 0.75 (0.56, 1.02) | 0.76 (0.54, 1.07) |
| Adjuvant chemo (yes vs no) | 1.37 (1.04, 1.80) | 1.60 (1.17, 2.19) |
CI = confidence interval; Cr = creatinine (mg/dl); eGFR = estimated glomerular filtration rate; OR = odds ratio; Ref = reference.
A total of 732 patients had a preoperative eGFR of >60 ml/min/1.73 m2 and reached an eGFR of <45 ml/min/1.73 m2 after cystectomy, while 1092 patients had a preoperative eGFR of >60 ml/min/1.73 m2and reached an eGFR of <60 ml/min/1.73 m2 after cystectomy.