Figure 3.
Selection of three key modulators of m6A RNA methylation
(A) Overall-survival-related regulators in patients with osteosarcoma analyzed via univariate Cox regression hazard analysis. (B) The least absolute shrinkage and selection operator (LASSO) regression analysis of the selected three factors: RBM15, METTL3, and LRPPRC. (C) 10-fold cross-validation used for adjusting parameter selection in the LASSO regression model. Vertical solid lines indicate partial likelihood deviance with standard errors. The vertical dashed line represents the best value of the adjustment parameter (λ) in terms of the minimum standard.