Fig. 1.

The diagram of this study. We performed comparative analysis to identify four types of differential molecular alterations (somatic mutation, CNV, DNA methylation, mRNA expression) between AA and CA. The detected alterations were then mapped to an interaction network on gene level. We next applied network propagation to prioritize genes associated with racial disparity in prostate cancer. Based on FDR < 0.01, we identified 130 DAGs underlying racial disparity and characterized them in terms of function and pathways, prognostic value as well as kinases and transcription factors within them.