Fig. 4.

Association of DAGs with incidence risk and mortality of prostate cancer. (A): DAGs have higher essentialities compared to non-DAGs, represented by lower CERES score (Wilcoxon rank-sum test). (B): DAGs were enriched for GWAS genes compared to non-DAGs (Fisher's exact test). GWAS gene: genes corresponding to prostate cancer risk SNPs in GWAS studies. (C): Genetic risk of the six GWAS genes within a DAG as measured by corresponding risk allele's odds ratio. (D): The DAGs were enriched for prognostic genes compared to non-DAGs (Fisher's exact test). (E): Hazard ratio and corresponding p values for the prognostic DAGs. (F and G): Survival difference between patients with high and low expression of YWHAZ (F) and JUN (G) with mean as cut-off (log-rank test).