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. 2021 Apr 23;13(10):809–823. doi: 10.2217/epi-2020-0414

Figure 2. . The ARID1-containing proteins are mutually exclusive subunits of the BRG1/BRM-associated factor complexes.

Figure 2. 

(A) Scheme of the BAF complex based on the model of Mashtalir et al. [9]. Mutually exclusive ARID1 proteins (ARID1A and ARID1B) play important role in the BAF complex assembly. They bind to subunits of the BAF core module and recruit subunits of ATPase module to form fully functioning complex. Subunits of the BAF core module are shown in blue, subunits of the BAF ATPase module are shown in green. ATPase catalytic subunit is either BRG1 (SMARCA4) or BRM (SMARCA2). (B) Schematic domain structure of ARID1 proteins was generated using Illustrator for Biological Sequences tool [82]. Similar motifs and domains are apparent between the amino acid sequences of ARID1A and ARID1B. Red boxes denote the ARID, vertical pink lines indicate LXXLL motifs, vertical orange lines indicate nuclear localizing signal.

BAF: BRG1/BRM-associated factor.