Table 4.

Relationship between adverse reactions and vaccination responses.

		Number of participants	Antibody titer of post-vaccine samples, AU/mL (mean ± SD)
Adverse reactions after the first dose
All
	No	245	14,727.2 ± 8,844.6	P = 0.119
	Yes	398	15,941.2 ± 9,988.4
Local reactions
	No	289	14,957.1 ± 9,150.2	p = 0.213
	Yes	354	15,904.4 ± 9,909.3
General fatigue
	No	506	15,243.8 ± 9,542.3	p = 0.233
	Yes	137	16,346.1 ± 9,703.3
GI symptoms
	No	623	15,527.3 ± 9,520.3	p = 0.473
	Yes	20	13,963.4 ± 11,462.5
Fever
	No	604	15,187.2 ± 9,270.8	P = 0.002
	Yes	39	19,992.8 ± 12,820.5
Quality of daily living affected
	Not so much	161	15,541.3 ± 10,365.4	P = 0.035
	Some how	213	15,696.5 ± 9,204.0
	Largely	23	21,178.2 ± 13,095.7
Adverse reactions after the second dose
All
	No	115	11,989.7 ± 7,891.7	P < 0.001
	Yes	514	16,726.3 ± 9,802.8
Local reactions
	No	256	14,764.2 ± 9,043.0	P = 0.116
	Yes	373	15,992.5 ± 9,978.7
General fatigue
	No	240	13,629.5 ± 9,463.3	P < 0.001
	Yes	389	16,642.0 ± 9,548.1
GI symptoms
	No	582	15,359.8 ± 9,497.4	P = 0.224
	Yes	47	17,136.8 ± 11,013.7
Fever
	No	342	12,957.9 ± 8,285.6	P < 0.001
	Yes	287	18,513.0 ± 10,244.3
Quality of daily living affected
	Not so much	87	13,154.9 ± 8,424.5	P < 0.001
	Some how	228	15,328.2 ± 9,138.4
	Largely	199	18,727.2 ± 10,538.1

GI, gastrointestinal.