Table 7. Correlation analysis of PVS with brain atrophy linear indexes and the severity of disability in MS.
| Variables | Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|---|
| P value | OR | 95% CI | P value | OR | 95% CI | ||
| PVS score | 0.452 | 0.843 | 0.54–1.316 | 0.344* | 0.775 | 0.458–1.313 | |
| Total number of PVSs | 0.898 | 1.001 | 0.989–1.013 | 0.874* | 1.001 | 0.987–1.016 | |
| Total number of EPVS | 0.283 | 0.97 | 0.917–1.026 | 0.41* | 0.973 | 0.913–1.038 | |
| CCI | 0.007 | 0.495 | 0.296–0.828 | 0.006# | 0.479 | 0.284–0.808 | |
| CCA, cm2 | 0.027 | 0.677 | 0.479–0.957 | 0.013# | 0.619 | 0.423–0.906 | |
| CCR | 0.009 | 0.515 | 0.303–0.849 | 0.005# | 0.466 | 0.274–0.792 | |
| u3VW, mm | 0.023 | 1.437 | 1.051–1.963 | 0.022# | 1.446 | 1.055–1.981 | |
| a3VW, mm | 0.014 | 1.487 | 1.084–2.038 | 0.013# | 1.499 | 1.090–2.061 | |
*, after controlling for gender, age, hypertension, recurrence frequency and duration of disease; #, after controlling for gender and age. MS, multiple sclerosis; PVS, perivascular space; EPVS, enlarged perivascular space; CCI, corpus callosum index; CCA, corpus callosum area; CCR, ratio of the corpus callosum to the cranium; a3VW, aligned third ventricle width; u3VW, unaligned third ventricle width.