. 2022 Feb;12(2):1004–1019. doi: 10.21037/qims-21-705

Table 8. Correlation analysis of PVS and brain atrophy linear indexes in the MS group and healthy control group.

Variables	rs/P	MS group (n=82)			Control group (n=32)
Variables	rs/P	PVS score	Total number of PVS	Total number of EPVS	PVS score	Total number of PVS	Total number of EPVS
Age	rs	0.352	0.353	0.258	0.059	0.26	−0.173
Age	P	0.001	0.001	0.019	0.748	0.151	0.344
Gender	rs	0.129	0.122	0.118	0.437	0.128	0.097
Gender	P	0.249	0.273	0.29	0.012	0.485	0.597
Hypertension	rs	0.296	0.289	0.128	0.281	0.252	-0.005
Hypertension	P	0.007	0.008	0.253	0.12	0.165	0.979
Recurrence times	rs	−0.075	−0.145	−0.117	–	–	–
Recurrence times	P	0.501	0.193	0.297	–	–	–
Duration of disease (months)	rs	−0.046	−0.128	−0.219	–	–	–
Duration of disease (months)	P	0.683	0.252	0.148	–	–	–
EDSS	rs	−0.094	−0.129	−0.016	–	–	–
EDSS	P	0.399	0.25	0.889	–	–	–
CCI	rs	0.033	0.176	0.049	−0.185	−0.071	−0.07
CCI	P	0.767	0.113	0.66	0.309	0.701	0.704
CCA, cm²	rs	0.272	0.255	0.058	0.088	0.021	−0.066
CCA, cm²	P	0.013	0.021	0.607	0.633	0.91	0.722
CCR	rs	0.219	0.201	−0.006	−0.05	−0.078	−0.055
CCR	P	0.048	0.071	0.956	0.784	0.672	0.766
u3VW, mm	rs	−0.073	−0.199	0.032	0.016	0.145	0.056
u3VW, mm	P	0.517	0.073	0.778	0.932	0.429	0.76
a3VW, mm	rs	−0.097	−0.201	0.001	0.043	0.173	0.022
a3VW, mm	P	0.387	0.071	0.995	0.816	0.345	0.904
CCI*	rs	0.089	0.156	0.087	−0.200	−0.106	−0.221
CCI*	P	0.433	0.168	0.044	0.289	0.577	0.241
CCA, cm²*	rs	0.177	0.173	0.098	0.061	0.031	−0.237
CCA, cm²*	P	0.117	0.126	0.386	0.747	0.872	0.207
CCR*	rs	0.147	0.119	0.058	−0.072	−0.116	−0.273
CCR*	P	0.193	0.291	0.607	0.704	0.543	0.144

*, partial correlation analysis after adjusting for age and hypertension. MS, multiple sclerosis; PVS, perivascular space; EPVS, enlarged perivascular space; EDSS, extended disability status scale; CCI, corpus callosum index; CCA, corpus callosum area; CCR, ratio of the corpus callosum to the cranium; a3VW, aligned third ventricle width; u3VW, unaligned third ventricle width.