Table 3.

Subgroup analyses of the association between immune-related adverse events and OS

	HR(95%CI)	p	P heterogeneity	I2 (%)
IrAEs type
Endocrine	0.50 (0.41–0.62)	< 0.001	0.160	32.2%
Gastrointestinal	0.61 (0.47–0.79)	< 0.001	0.853	0.0%
Hepatobiliary	0.99 (0.73–1.35)	0.971	0.940	0.0%
Pulmonary	1.09 (0.85–1.40)	0.497	0.003	71.9%
Skin	0.53 (0.42–0.67)	< 0.001	0.311	16.0%
IrAEs grade
Low-grade(1–2)	0.70 (0.49–0.99)	0.045	0.236	29.3%
Severe-grade(≥ 3)	0.93 (0.74–1.16)	0.531	0.003	71.8%