Table 11.
The relationship between MTHFR C677T, MTHFR A1298C, ABCB1 C3435T and MTX-related toxicities.
| Polymorphisms (n) | Mucositis | Hepatotoxicity | Nephrotoxicity | Hematopoietic toxicity | ||||
|---|---|---|---|---|---|---|---|---|
| P-value | OR (95% CI) | P-value | OR (95% CI) | P-value | OR (95% CI) | P-value | RC (95% CI) | |
| MTHFR C677T | ||||||||
| CC (14) | – | – | – | – | – | – | – | – |
| CT+TT (16) | 0.586 | 0.592 (0.09-3.907) | 0.997 | 1.003 (0.187-5.387) | 0.791 | 0.786 (0.132-4.664) | 0.003 | 1.388 (0.506-2.269) |
| MTHFR A1298C | ||||||||
| AA (19) | – | – | – | – | – | – | – | – |
| AC+CC (11) | 0.203 | 3.717 (0.492-28.064) | 0.798 | 0.79 (0.13-4.813) | 0.206 | 3.434 (0.508-23.228) | 0.361 | 0.411 (-0.5-1.322) |
| ABCB1 C3435T | ||||||||
| CC (16) | – | – | – | – | – | – | – | – |
| CT+TT (14) | 0.752 | 1.367 (0.196-9.51) | 0.264 | 2.898 (0.447-18.775) | 0.857 | 0.838 (0.123-5.709) | 0.055 | -0.913 (-1.845-0.019) |
| Gender | ||||||||
| Female (11) | – | – | – | – | – | – | – | – |
| Male (19) | 0.024 | 9.006 (1.327-61.116) | 0.404 | 0.475 (0.083-2.725) | 0.349 | 2.623 (0.349-19.704) | 0.402 | 0.373 (-0.53-1.276) |
| Age | 0.268 | 0.955 (0.88-1.036) | 0.244 | 0.949 (0.87-1.036) | 0.219 | 0.938 (0.848-1.038) | 0.257 | 0.023 (-0.018-0.064) |
(TLBL & ALL & CML-LBC Dose: 2.5-5g/m2).
Bold values means that p value ＜0.05, and the related data is significant statistically.