Table 13.
The relationship between MTHFR C677T, MTHFR A1298C, ABCB1 C3435T and MTX-related toxicities.
| Polymorphisms (n) | Mucositis | Hepatotoxicity | Nephrotoxicity | Hematopoietic toxicity | ||||
|---|---|---|---|---|---|---|---|---|
| P-value | OR (95% CI) | P-value | OR (95% CI) | P-value | OR (95% CI) | P-value | RC (95% CI) | |
| MTHFR C677T | ||||||||
| CC (6) | – | – | – | – | – | – | – | – |
| CT+TT (9) | 0.999 | 0 (0-) | 0.953 | 1.112 (0.032-39.075) | 0.787 | 1.387 (0.13-14.801) | 0.279 | -0.864 (-2.559-0.831) |
| MTHFR A1298C | ||||||||
| AA (14) | – | – | – | – | – | – | – | – |
| AC+CC (1) | 1 | 3.936 (0-) | 1 | 0 (0-) | 1 | 0 (0-) | 0.044 | -3.62 (-7.123—0.116) |
| ABCB1 C3435T | ||||||||
| CC (2) | – | – | – | – | – | – | – | – |
| CT+TT (13) | 0.999 | 0 (0-) | 0.999 | 0 (0-) | 0.714 | 0.561 (0.026-12.332) | 0.75 | -0.347 (-2.738-2.045) |
| Gender | ||||||||
| Female (6) | – | – | – | – | – | – | – | – |
| Male (9) | 0.999 | 0 (0-) | 0.153 | 0.061 (0.001-2.832) | 0.904 | 0.866 (0.084-8.925) | 0.354 | -0.757 (-2.51-0.995) |
| Age | 0.701 | 1.052 (0.811-1.365) | 0.215 | 0.881 (0.721-1.076) | 0.716 | 0.981 (0.883-1.089) | 0.864 | -0.006 (-0.077-0.066) |
(NK/T cell lymphoma & ANKL Dose: 2.5-5g/m2).
Bold values means that p value < 0.05, and the related data is significant statistically.