Table 4.
The relationship between MTHFR C677T, MTHFR A1298C, ABCB1 C3435T and MTX-related toxicities.
| Polymorphisms (n) | Mucositis | Hepatotoxicity | Nephrotoxicity | Hematopoietic toxicity | ||||
|---|---|---|---|---|---|---|---|---|
| P-value | OR (95% CI) | P-value | OR (95% CI) | P-value | OR (95% CI) | P-value | RC (95% CI) | |
| MTHFR C677T | ||||||||
| CC (38) | – | – | – | – | – | – | – | – |
| CT+TT (59) | 0.788 | 0.886 (0.367-2.141) | 0.912 | 1.055 (0.409-2.717) | 0.462 | 1.559 (0.478-5.082) | 0.051 | 0.52 (-0.003-1.043) |
| MTHFR A1298C | ||||||||
| AA (60) | – | – | – | – | – | – | – | – |
| AC+CC (37) | 0.354 | 1.53 (0.622-3.762) | 0.58 | 1.306 (0.508-3.36) | 0.224 | 2.072 (0.64-6.706) | 0.916 | 0.028 (-0.501-0.557) |
| ABCB1 C3435T | ||||||||
| CC (45) | – | – | – | – | – | – | – | – |
| CT+TT (52) | 0.954 | 0.976 (0.418-2.276) | 0.779 | 1.138 (0.459-2.822) | 0.146 | 0.427 (0.135-1.346) | 0.171 | -0.349 (-0.852-0.153) |
| Gender | ||||||||
| Female (34) | – | – | – | – | – | – | – | – |
| Male (63) | 0.151 | 1.892 (0.792-4.521) | 0.315 | 0.623 (0.248-1.566) | 0.092 | 3.268 (0.826-12.94) | 0.762 | 0.08 (-0.443-0.603) |
| Age | 0.434 | 0.987 (0.956-1.019) | 0.485 | 0.988 (0.954-1.023) | 0.58 | 1.012 (0.971-1.054) | 0.738 | -0.003 (-0.022-0.016) |
(TLBL & ALL & CML-LBC).