Table 5.
The relationship between MTHFR C677T, MTHFR A1298C, ABCB1 C3435T and MTX-related toxicities.
| Polymorphisms (n) | Mucositis | Hepatotoxicity | Nephrotoxicity | Hematopoietic toxicity | ||||
|---|---|---|---|---|---|---|---|---|
| P-value | OR (95% CI) | P-value | OR (95% CI) | P-value | OR (95% CI) | P-value | RC (95% CI) | |
| MTHFR C677T | ||||||||
| CC (14) | – | – | – | – | – | – | – | – |
| CT+TT (24) | 0.064 | 5.511 (0.905-33.55) | 0.833 | 0.84 (0.167-4.236) | 0.999 | 0 (0-) | 0.056 | 1.038 (-0.03-2.106) |
| MTHFR A1298C | ||||||||
| AA (26) | – | – | – | – | – | – | – | – |
| AC+CC (12) | 0.803 | 1.256 (0.209-7.561) | 0.281 | 2.831 (0.427-18.787) | 0.999 | 6.522*1012 (0-) | 0.221 | 0.721 (-0.455-1.896) |
| ABCB1 C3435T | ||||||||
| CC (13) | – | – | – | – | – | – | – | – |
| CT+TT (25) | 0.085 | 4.644 (0.807-26.719) | 0.422 | 2.044 (0.357-11.693) | 0.997 | 6.378*1024 (0-) | 0.431 | 0.411 (-0.64-1.462) |
| Gender | ||||||||
| Female (15) | – | – | – | – | – | – | – | – |
| Male (23) | 0.526 | 0.581 (0.109-3.107) |
0.762 | 0.762 (0.131-4.421) |
0.997 | 0 (0-) |
0.084 | -0.96 (-2.059-0.138) |
| Age | 0.996 | 1 (0.946-1.057) |
0.365 | 0.972 (0.915-1.033) |
0.991 | 421.686 (0-) |
0.172 | -0.026 (-0.063-0.012) |
(DLBCL & Burkitt lymphoma & MCL & FL).