Table 7.
The relationship between MTHFR C677T, MTHFR A1298C, ABCB1 C3435T and MTX-related toxicities.
| Polymorphisms (n) | Mucositis | Hepatotoxicity | Nephrotoxicity | Hematopoietic toxicity | ||||
|---|---|---|---|---|---|---|---|---|
| P-value | OR (95% CI) | P-value | OR (95% CI) | P-value | OR (95% CI) | P-value | RC (95% CI) | |
| MTHFR C677T | ||||||||
| CC (32) | – | – | – | – | – | – | – | – |
| CT+TT (67) | 0.68 | 1.212 (0.486-3.019) | 0.462 | 1.472 (0.526-4.123) | 0.276 | 2.741 (0.448-16.784) | 0.311 | 0.29 (-0.275-0.854) |
| MTHFR A1298C | ||||||||
| AA (59) | – | – | – | – | – | – | – | – |
| AC+CC (40) | 0.638 | 1.232 (0.516-2.941) | 0.359 | 1.559 (0.603-4.032) | 0.387 | 1.977 (0.422-9.25) | 0.96 | -0.013 (-0.549-0.523) |
| ABCB1 C3435T | ||||||||
| CC (42) | – | – | – | – | – | – | – | – |
| CT+TT (57) | 0.501 | 1.34 (0.572-3.141) | 0.456 | 1.435 (0.556-3.705) | 0.438 | 0.515 (0.096-2.756) | 0.753 | -0.084 (-0.612-0.444) |
| Gender | ||||||||
| Female (36) | – | – | – | – | – | – | – | – |
| Male (63) | 0.79 | 1.122 (0.479-2.628) |
0.417 | 0.683 (0.273-1.713) |
0.121 | 5.866 (0.628-54.781) |
0.316 | -0.267 (-0.793-0.259) |
| Age | 0.439 | 0.988 (0.959-1.018) |
0.778 | 0.995 (0.963-1.029) |
0.245 | 1.032 (0.978-1.089) |
0.112 | -0.015 (-0.034-0.004) |
(Dose: 1-2g/m2).