Table 8.
The relationship between MTHFR C677T, MTHFR A1298C, ABCB1 C3435T and MTX-related toxicities.
| Polymorphisms (n) | Mucositis | Hepatotoxicity | Nephrotoxicity | Hematopoietic toxicity | ||||
|---|---|---|---|---|---|---|---|---|
| P-value | OR (95% CI) | P-value | OR (95% CI) | P-value | OR (95% CI) | P-value | RC (95% CI) | |
| MTHFR C677T | ||||||||
| CC (24) | – | – | – | – | – | – | – | – |
| CT+TT (43) | 0.684 | 0.799 (0.271-2.355) | 0.928 | 1.056 (0.323-3.456) | 0.297 | 2.632 (0.427-16.212) | 0.804 | 0.082 (-0.578-0.743) |
| MTHFR A1298C | ||||||||
| AA (41) | – | – | – | – | – | – | – | – |
| AC+CC (26) | 0.726 | 1.209 (0.418-3.496) | 0.393 | 1.651 (0.523-5.21) | 0.594 | 1.566 (0.301-8.146) | 0.48 | -0.231 (-0.881-0.419) |
| ABCB1 C3435T | ||||||||
| CC (29) | – | – | – | – | – | – | – | – |
| CT+TT (38) | 0.822 | 0.886 (0.31-2.536) | 0.893 | 0.924 (0.294-2.905) | 0.593 | 0.625 (0.112-3.499) | 0.337 | -0.311 (-0.954-0.331) |
| Gender | ||||||||
| Female (23) | – | – | – | – | – | – | – | – |
| Male (44) | 0.909 | 1.063 (0.371-3.048) |
0.421 | 0.629 (0.203-1.946) |
0.13 | 5.715 (0.6-54.415) |
0.763 | -0.098 (-0.745-0.549) |
| Age | 0.668 | 0.992 (0.956-1.029) |
0.721 | 0.993 (0.953-1.033) |
0.181 | 1.039 (0.982-1.099) |
0.564 | -0.007 (-0.029-0.016) |
(TLBL & ALL & CML-LBC Dose: 1-2g/m2).