Table 9.
The relationship between MTHFR C677T, MTHFR A1298C, ABCB1 C3435T and MTX-related toxicities.
| Polymorphisms (n) | Mucositis | Hepatotoxicity | Nephrotoxicity | Hematopoietic toxicity | ||||
|---|---|---|---|---|---|---|---|---|
| P-value | OR (95% CI) | P-value | OR (95% CI) | P-value | OR (95% CI) | P-value | RC (95% CI) | |
| MTHFR C677T | ||||||||
| CC (7) | – | – | – | – | – | – | – | – |
| CT+TT (18) | 0.128 | 7.468 (0.56-99.641) | 0.424 | 2.945 (0.209-41.601) | – | (-) | 0.17 | 0.885 (-0.414-2.183) |
| MTHFR A1298C | ||||||||
| AA (15) | – | – | – | – | – | – | – | – |
| AC+CC (10) | 0.973 | 0.959 (0.086-10.738) | 0.478 | 2.676 (0.176-40.658) | – | (-) | 0.309 | 0.72 (-0.722-2.162) |
| ABCB1 C3435T | ||||||||
| CC (10) | – | – | – | – | – | – | – | – |
| CT+TT (15) | 0.143 | 5.888 (0.55-62.986) | 0.23 | 5.535 (0.339-90.336) | – | (-) | 0.166 | 0.889 (-0.402-2.179) |
| Gender | ||||||||
| Female (10) | – | – | – | – | – | – | – | – |
| Male (15) | 0.698 | 0.617 (0.054-7.099) |
0.906 | 0.848 (0.056-12.913) |
– | (-) | 0.123 | -1.098 (-2.524-0.328) |
| Age | 0.992 | 1 (0.93-1.075) |
0.495 | 0.97 (0.889-1.059) |
– | (-) | 0.5 | -0.015 (-0.062-0.031) |
(DLBCL & Burkitt lymphoma & MCL & FL Dose: 1-2g/m2).