Fig. 4.

A nanosized biocatalyst for energy depletion enhanced mPTT. (A) Schematic illustration of the synthesis of PHPBNs-S-S-HA-PEG@GOx and GOx-mediated starvation synergizing with low-temperature photothermal therapy; (B) Changes of tumor volumes and (C) the survival rate of HepG2 tumor-bearing mice in different groups; (D, E) Quantitative fluorescence analysis of the (E) HSP90 and (F) HSP70 expression after treatment with PBS (I), PBS + NIR (II), PHPBNs-S-S-HA-PEG (III), PHPBNs-S-S-HA-PEG@GOx (IV), PHPBNs-PEG + NIR (V), PHPBNs-S-S-HA-PEG + NIR (VI), and PHPBNs-S-S-HA-PEG@GOx + NIR (VII) for 21 d, respectively. (n = 6, **P < 0.01). Reproduced with permission from [47]. Copyright 2018 American Chemical Society.