Fig. 6.

Plasmonic Au-nanocomposites induced mPTT to enhance deep penetration in tumor. (A) Synthetic process of Gd-hybridized plasmonic Au-nanocomposites loading high Dox and modified with HA; (B) In vivo PA imaging of NCs in no laser group or laser group. The gray section notes the signal intensity of hemoglobin, while the color section notes that of NCs; (C) Mean PA signal intensities of tumor region with or without laser at 1 h, 6 h and 24 h. (D) SR-XRF mapping of Au and Gd of the tumor maximum transverse sections. Scale bar: 1 mm; (E) Immunofluorescence images of the tumor slices staining with CD31. Scale bar: 100 µm. Reproduced with permission from [64]. Copyright 2016 Wiley.