Fig. 7.

GNRS-meditated mPTT for enhancing chemotherapeutics accumulation. (A) Synthetic process of Tf-GNRS; (B) MSOT analysis of GNRS and Tf-GNRS distributions in tumor with or without irradiation (0.5 W/cm², 1 min × 3 times, 1 min interval). The white circles mark the tumor regions. Scale bars, 5 mm; (C) Quantitative analysis of the intratumoral signal intensity of GNRS and Tf-GNRS; (D) H&E staining treated with GNRS and Tf-GNRS plus laser irradiation of MIA-PaCa-2 tumor, arrow indicates the blood perfusion of tumor section. Scale bars, 100 µm. (*P < 0.05, **P < 0.01). Reproduced with permission from [61]. Copyright 2017 American Chemical Society.