Fig. 13.
TiH1.924 and TiN nanodots-potentiated mPTT synergizing with SDT for tumor ablation. (A) Preparation of TiH1.924 nanodots via light-phase exfoliation; (B) Fluorescence images of ROS in 4T1 cells treated with TiH1.924 nanodots as detected by DCFH-DA probe. The ROS was indicated as green and the nuclei were stained with DAPI and shown as blue; (C) In vivo hypoxia staining of tumors treated by TiH1.924 nanodots. The blood vessels marker CD31 and hypoxia probe pimonidazole were indicated as red and green respectively, with the nuclei stained by DAPI (blue); (D) Schematic diagram of the fabrication of TiN nanodots and the following decoration; (E) Fluorescence images of ROS in 4T1 cells treated with TiN nanodots; (F) The in vivo hypoxia staining of tumors treated by TiN nanodots. (A C) are reproduced with permission from [125]. Copyright 2020 Springer Nature. (D F) are reproduced with permission from [124]. Copyright 2021 Elsevier.