Skip to main content
. 2021 Oct 15;16(6):738–761. doi: 10.1016/j.ajps.2021.10.001

Table 1.

Nanomedicine-potentiated strategies for enhancing mPTT.

Strategy Nanomedicine Therapeutic agent Target Therapeutic temperature Ref.
Small molecular inhibitors
  • -

    Qu-FeIIP

 Quercetin HSP70 45 °C [29]
  • -

    Mn-ICG@pHis-PEG/GA

 GA HSP90 ∼43 °C [30]
  • -

    Smart albumin-based theranostic nanoagent (HSA/dc-IR825/GA)

 GA HSP90 < 45 °C [31]
  • -

    Thermosensitive GOx/ICG/GA liposomes (GOIGLs)

 GA HSP90 41∼42 [22]
  • -

    GO–GA-polymer scaffold

 GA HSP90 45 °C [32]
  • -

    Bi2Se3 hollow nanocubes (HNC-s-s-HA/GA)

 GA HSP90 ∼ 43 °C [33]
  • -

    Hollow mesoporous carbon spheres (HMCS-PEG-GA)

 GA HSP90 43 °C [34]
  • -

    Bovine serum albumin/canine dye 7/geldanamycin nanoparticles (BSA/Cy7-SQ/GM)

 GM HSP90 43 °C [35]
  • -

    HSP90 inhibitor-delivered flowerlike short-wave infrared nanoprobe (Lu:Nd@NiS2-EGCG)

 Epigallocatechin gallate (EGCG) HSP90 45 °C [18]
  • -

    Boron-based multifunctional nanoplatform (Dox-17AAG@B-PEG-cRGD)

 17AAG HSP90 43 °C [36]
  • -

    Folic acid incorporated SNX-2112 loaed GO nanosheets (GFS)

 SNX-2112 HSP90 45 °C [37]
  • -

    Therapy-induced nanohybrid ICD amplifier (FeOOH@STA/Cu-LDH)

 STA-9090 HSP90 40∼42 °C [38]
  • -

    BIIB021-loaded IR780 nano-micelles (PEG-IR780-BIIB021)

 BIIB021 HSP90 45 °C [39]
  • -

    NVP-AUY922 loaded GO/BaHoF5/PEG nanocomposite (GO/BaHoF5/PEG/AUY922)

 NVP-AUY922 HSP90 < 45 °C [40]
  • -

    Multifunctional LY294002-loaded Bi2S3–Tween 20 nanotheranostic (Bi2S3–Tween 20@LY294002)

 LY294002 PI3K (PI3K/Akt/GSK3/HSP) pathway 45 °C [41]
  • -

    MPEG coated gold nanorod and VER-155,008 micelles (MPEG-AuNR@VER-M)

 VER-155,008 HSP70
HSP90		 45 °C [5]
Gene regulation
  • -

    Hollow gold nanoshells conjugated with siHSP70 (HGN-siHSP70)

 siRNA HSP70 < 48 °C [42]
  • -

    PP-NG

 siRNA HSP70 42∼45 °C [43]
  • -

    siRNA-loaded zirconium-ferriporphyrin metal–organic framework nanoshuttle (siRNA/Zr-FeP MOF)

 siRNA HSP70 45 °C [44]
  • -

    CRISPR-Cas9 nanosystem based on gold nanorods (APACPs)

 Cas9 RNP HSP90α 42 °C [45]
  • -

    CuS-RNP/Dox@PEI

 Cas9 RNP HSP90α ∼ 43 °C [46]
Ferroptosis
  • -

    Pd SAzyme

 LPO/ROS HSPs 42 °C [6]
Starvation therapy
  • -

    GOIGLs

 GOx Glucose 41∼42 °C [22]
  • -

    PHPBNs-S-S-HA-PEG@GOx

 GOx Glucose 45 °C [47]
  • -

    PDA@hm@CQ@GOx

 GOx Glucose 45 °C [48]
  • -

    MnO2 nanosheets (M-NS)

 MnO2 Glucose 46 °C [49]
  • -

    Rod-shape inorganic biomimetic MnO2–Au nanozymes (MSNR@MnO2-Au)

 Ultrasmall Au nanoparticle Glucose < 50 °C [50]
  • -

    Gold nanorods/HA/Diclofenac nanosystem (GNR/HA-DC)

 DC Glut1 (Glucose transporters) < 50 °C [51]
  • -

    CuS-based NO gas nanogenerator (CuS-PEI/NO-TPP)

 NO Mitochondria 46 °C [52]