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. 2021 Oct 15;16(6):738–761. doi: 10.1016/j.ajps.2021.10.001

Table 2.

Nanomedicine-promoted strategies for mPTT synergized with chemotherapy.

Improved chemotherapy efficacy by Mptt Nanomedicine PTA Chemotherapeutic agents Mechanisms Ref.
Cellular uptake
  • -

    HSA-ICG-PTX

 ICG PTX
  • -

    Enhance cell membrane permeability

 [25]
  • -

    Zwitterionic polypeptide nanomedicine

 AuNRs Dox [57]
  • -

    Triple stimuli-responsive polymer–drug conjugate nanoparticles

 PDA Chlorambucil [58]
  • -

    CuS@BSA-HMONs-Dox

 CuS Dox [59]
  • -

    PLGA/PPy loaded DTX

 Polypyrrole (PPy) Docetaxel (DTX) [60]
  • -

    PEGylated AuNRs

 AuNRs HPMA copolymers
  • -

    Increase blood perfusion

 [20]
  • -

    Gold nanoshell@mesoporous silica nanorod

 AuNRs Gemcitabine
  • -

    Destroy dense tumor stroma barrier

 [61]
  • -

    TMZ/PSi NPs

 Porous silicon (PSi) Temozolomide (TMZ)
  • -

    Improve oxygen supply

 [62]
  • -

    PSN—HSA-PTX-IR780

 IR780 PTX
  • -

    Induce tissue injury

 [63]
Drug release
  • -

    Au@SiO2 (Gd)@PDC@HA

 Au Dox
  • -

    Disrupt interaction between nanocarrier and drug

 [64]
  • -

    CuS@BSA-HMONs-Dox

 CuS Dox [59]
  • -

    Dox-SWNH/DCA-HPCHS

 Single-walled carbon Dox [65]
  • -

    aHLP (acid-activated hemolytic polymer)–PDA nanoparticle

 PDA aHLP [66]
  • -

    Multimodal selenium nanoshell-capped Au@mSiO2 nanoplatform

 Au Dox [67]
  • -

    PDA-ALN-SN38

 PDA SN38 [68]
  • -

    PNOC-PDA/NO/Dox

 PDA Dox [69]
  • -

    Zwitterionic polypeptide nanomedicine

 AuNRs Dox
  • -

    Enhance drug diffusion

 [57]
  • -

    Ag2S QD coating with dendritic mesoporous silica (DMSN) loaded with Dox

 Ag2S Dox [70]
  • -

    Triple stimuli-responsive polymer–drug conjugate nanoparticles

 PDA Chlorambucil [58]
  • -

    Gold-nanodot-decorated hollow carbon nanospheres loaded with Dox

 Gold-nanodot-decorated hollow carbon Dox [71]
  • -

    Thermosensitive Liposomes

 Au Dox
  • -

    Trigger disassembly of thermosensitive

 [72]
  • -

    Mild-heat-inducible sequentially released liposomal complex

 AuNRs STS [73]
  • -

    Thermo-sensitive liposome coated gold nanocages with Dox loading

 Au Dox [74]
  • -

    Gold nanorod-cored biodegradable micelles

 AuNRs Dox [75]
  • -

    UCNPs@ZrO2—Ce6/Dox/PCM

 Nd3+-doped upconversion nanoparticle Dox [76]
  • -

    5-FU/Cu-LDH@NAB-PTX

 Cu 5-FU, PTX [77]
  • -

    Ag2S QD coating with dendritic mesoporous silica loaded with Dox

 Ag2S Dox
  • -

    Improve oxygen supply

 [70]
  • -

    Melanin coated magnetic nanoparticles

 Melanin Obatoclax (OBX)
  • -

    Trigger specific response of NPs

 [78]
Drug resistance
  • -

    MoS2-PEI-HA/Dox

 MoS2 Dox
  • -

    Down-regulate P-gp

 [79]
  • -

    Gold-nanodot-decorated hollow carbon nanospheres loaded with Dox

 Gold-nanodot-decorated hollow carbon Dox
  • -

    Down-regulate mutant p53, P-gp, MDR-1, IKKa, p-IKKa, p-IκB, p65, p-p65

  • -

    Up-regulate HSF-1 trimers

 [71]
  • -

    PNOC-PDA/NO/Dox

 PDA Dox [69]
  • -

    Au@SiO2 nanoplatform

 Au Dox [80]
  • -

    Thermo-sensitive liposome coated gold nanocages

 Au Dox
  • -

    Down-regulate mutant p53, P-gp, HSF-1

 [74]
  • -

    F-Pt-NPs

 Pt Cisplatin
  • -

    Facilitate cisplatin uptake

  • -

    Accelerate GSH depletion

  • -

    Increase cross-linking of Pt (II) with DNA

 [81]