Table 2.
Results for Child Physical Health Outcomesa
| Study | Child Age at Testing | Outcome | Comparison Groups | Adjusted Outcome | 95% CI | Covariates |
|---|---|---|---|---|---|---|
| Grzeskowiak et al 201246 | 4–5 y | BMI > 85th percentile (females only) | SSRIs (n = 33) vs unexposed (n = 3,072) | 0.27 | 0.07 to 0.99 | Maternal age, BMI, race, socioeconomic status, parity, smoking status, appropriateness of fetal growth (SGA/LGA), breastfeeding at discharge from hospital |
| SSRIs (n = 33) vs unmedicated psychiatric illness (n = 106) | 0.23 | 0.05 to 0.98 | ||||
| BMI > 85th percentile (males only) | SSRIs (n = 38) vs unexposed (n = 3,213) | 0.93 | 0.52 to 1.67 | |||
| SSRIs (n = 38) vs unmedicated psychiatric illness (n = 98) | 1.17 | 0.54 to 2.51 | ||||
| Grzeskowiak et al 201347 | 7 y | BMI > 85th percentile | SSRIs (n = 127) vs unexposed (n = 35,568) | 1.39 | 0.94 to 2.05 | Pre-pregnancy maternal BMI, weight gain during pregnancy, paternal BMI, employment status, smoking status, prenatal distress, maternal postnatal distress score, neonatal birth weight, breastfeeding |
| SSRIs (n = 127) vs unmedicated psychiatric illness (n=490) | 1.12 | 0.71 to 1.77 | ||||
| BMI > 85th percentile (females only) | SSRIs (n = 63) vs unexposed (n = 17,320) | 0.99 | 0.43 to 2.26 | |||
| SSRIs (n = 63) vs unmedicated psychiatric illness (n = 239) | 0.86 | 0.37 to 1.99 | ||||
| BMI > 85th percentile (males only) | SSRIs (n = 64) vs unexposed (n = 18,248) | 1.54 | 1.01 to 2.37 | |||
| SSRIs (n = 64) vs unmedicated psychiatric illness (n = 251) | 1.78 | 1.01 to 3.12 | ||||
| Liu et al 201555 | > 3 y | Asthma (medication and/or hospital contact) | Antidepressants (n = 8,895) vs unexposed (n = 712,314) | 1.25 | 1.18 to 1.33 | Maternal country of origin, parity, age at delivery, maternal social status at birth, smoking during pregnancy, maternal history of asthma, sex of the child, calendar year of birth |
| Antidepressants (n = 8,895) vs unmedicated prenatal depression (n = 12,476) | 1.00 | 0.93 to 1.08 | ||||
| Mao et al 201659 | < 13 y | Epilepsy (ICD-10 code G40–41) | Antidepressants (n = 12,438) vs unexposed (n = 715,319) | 1.27 | 1.05 to 1.54 | Child’s sex, family income at birth, maternal age at birth, education, marital status at birth, parity, parental epilepsy diagnosis history before birth, smoking |
| Momen et al 201861 | < 15 y | Childhood cancer (ICD-10: C00-C97) | Antidepressants (n = 21,488) vs unexposed (n = 863,033) | 1.15 | 0.78 to 1.72 | Maternal age at delivery, primiparity, maternal history of psychiatric disorders at delivery, inpatient psychiatric treatment from 2 years before pregnancy up to delivery, dispensation of other psychotropic prescriptions during pregnancy, smoking during pregnancy, maternal highest education, calendar year of delivery, parental cancer history at time of delivery |
| Antidepressants (n = 21,488) vs prior antidepressant users (n = 30,607) | 1.03 | 0.63 to 1.68 |
a
Values in bold are statistically significant. Adjusted outcomes are adjusted relative risks.
Abbreviations: BMI = body mass index, LGA = large for gestational age, SGA = small for gestational age, SSRI = selective serotonin reuptake inhibitor.